The Nebrodi Mountains, together with the Madonie to the west and the Peloritani to the east, make up the Sicilian Apennines. They face, to the north, directly onto the Tyrrhenian Sea, while their southern limit is marked by Mount Etna, in particular by the Alcantara river and the upper course of the Simeto.

The Nebrodi is a mountain range that runs along the north east of Sicily. Together with the Madonie and the Peloritani, they form the Sicilian Apennines. In 1993 large areas of the Nebrodi Mountains were made into national parkland that covers 856.87 km², one of the largest protected area in Sicily. The natural landscape of the Nebrodi is characterised by rich forests, wide green high-altitude pastures, silent lakes and flowing streams that contrast with the more common image of an arid, sun-baked Sicily. Livestock breeding (mainly cattle, but also horses) is practised there in a non-intensive manner, and there is an indigenous breed of pig (Nero dei Nebrodi) that lives in a semi-wild and wild state.